GHRP-2
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A synthetic hexapeptide GH secretagogue. GHRP-2 (Pralmorelin) stimulates strong pulsatile growth hormone release via the ghrelin receptor with minimal effect on cortisol, making it one of the most studied GHRPs for GH research. 5mg vial.
Compound Profile
Pharmaceutical Data Sheet
Mechanism of Action
How GHRP-2 Works
GHRP-2 is a synthetic hexapeptide and the most potent member of the growth hormone releasing peptide family. It acts as a selective agonist at the GHS-R1a receptor on pituitary somatotrophs, producing the strongest GH secretion of any GHRP studied. Compared to GHRP-6, GHRP-2 demonstrates superior GHS-R1a selectivity with significantly less appetite stimulation and reduced cortisol/prolactin elevation, making it the preferred GHRP for clean GH axis research.
- Highest-affinity GHRP at pituitary GHS-R1a
- Produces greatest GH pulse amplitude of any GHRP
- Calcium-dependent exocytosis of stored GH granules
- Synergistic with GHRH-R agonists (CJC-1295)
- Robust GH elevation drives hepatic IGF-1 production
- IGF-1 mediates tissue anabolism and repair
- Promotes lipolysis and lean body composition
- IGFBP-3 co-elevation extends circulating IGF-1 half-life
- Minimal hypothalamic appetite stimulation vs. GHRP-6
- Lower cortisol elevation than GHRP-6 or Hexarelin
- Modest prolactin increase β within physiological range
- Cleanest hormonal side-effect profile among GHRPs
GHRP-2 binds GHS-R1a with high affinity and selectivity, activating the Gq/11-PLC-IP3-calcium cascade. The D-Ala and D-Ξ²Nal substitutions confer enhanced receptor binding affinity compared to GHRP-6, translating to greater GH release per unit dose. The improved selectivity profile means reduced activation of hypothalamic appetite circuits and adrenal cortisol pathways.
Bowers CY et al., Endocrine (2004): Comparative potency of growth hormone secretagogues.
Preclinical Findings
Research Models
Clinical Data
Superior GH Secretagogue Potency Among GHRP Family
Head-to-head pharmacodynamic research consistently ranks GHRP-2 as the most potent GH secretagogue peptide, producing peak GH concentrations that exceed GHRP-6 and Ipamorelin while maintaining a cleaner hormonal side-effect profile than GHRP-6 or Hexarelin.
Bowers CY, J Clin Endocrinol Metab (1991): Comparative GH-releasing activity of GHRP analogs.
Human and rodent comparative pharmacodynamic studies
Research Outcomes
Key Research Success Metrics
Safety Profile
Research Safety Notes
- Minimal appetite stimulation β significantly less than GHRP-6
- Cortisol elevation modest and transient β lower than GHRP-6 or Hexarelin
- Prolactin increase within physiological range at standard research doses
- No carcinogenic or mutagenic signals in preclinical safety evaluations
- Pulsed administration recommended to preserve GH axis sensitivity β avoid continuous infusion
For research use only. GHRP-2 is the most potent GH secretagogue peptide and modulates the pituitary-somatotroph axis. Not for human therapeutic use.
About GHRP-2
A synthetic hexapeptide GH secretagogue. GHRP-2 (Pralmorelin) stimulates strong pulsatile growth hormone release via the ghrelin receptor with minimal effect on cortisol, making it one of the most studied GHRPs for GH research. 5mg vial.
All PureAmino Research compounds are manufactured to research-grade standards and independently tested by Janoshik Analytical & Kovera Labs. The Certificate of Analysis for this compound includes full HPLC chromatography data, mass spectrometry confirmation, net purity percentage, and net content verification.
Research Use Only
This product is strictly for in vitro research and laboratory use only. Not for human or veterinary consumption. By purchasing, you confirm use in a controlled research setting.
